DegronMD - Q7Z7J5(DPPA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E38K	TCGA-18-3409	LUSC	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	TCGA-CV-7248	HNSC	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	DO14806	HNSC	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	DO26444	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	DO220912	MELA	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	SIDM00545	Melanoma	GDSC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	ACH-000987	Skin Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38K	Mewo	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.D34G	TCGA-19-5956	GBM	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0556
p.D34G	DO13863	GBM	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0556
p.V44I	TCGA-AA-3506	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.7076
p.V44I	DO8063	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.7076
p.V44I	DO218694	GACA	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.7076
p.A35T	TCGA-AX-A3FT	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0833
p.A35T	DO40801	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0833
p.E41K	TCGA-D3-A8GI	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.25
p.E41K	DO50284	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.25
p.E53K	TCGA-DK-AA6L	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1944
p.E53K	DO219002	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1944
p.M40I	TCGA-EE-A181	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.M40I	TCGA-EE-A29M	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.M40I	TCGA-EE-A3JI	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.M40I	DO47268	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.M40I	DO37404	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.M40I	DO37444	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.E38V	TCGA-Z2-A8RT	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.E38V	DO51301	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.M37K	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1389
p.M37K	NCI-H460	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1389

Kaplan plot for DPPA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPPA2

UniProt ID: Q7Z7J5

Entrez ID: 151871

Protein name: Developmental pluripotency-associated protein 2 (Pluripotent embryonic stem cell-related gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPPA2 in