DegronMD - Q86SQ0(PHLDB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P551S	TCGA-12-0688	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.P551S	DO11088	GBM	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.R549Q	TCGA-16-1045	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.R549Q	DO234155	ESAD	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.R549Q	DO11800	GBM	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.E564Q	TCGA-BH-A209	BRCA	TCGA	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.E564Q	DO5590	BRCA	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.S563N	TCGA-BR-8059	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	553:557	Mutation blocking phosphorylation signal	0.6111
p.S563N	DO38443	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation blocking phosphorylation signal	0.6111
p.P559R	TCGA-EE-A2M6	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.P559R	DO222514	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.P559R	DO37976	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.S555F	TCGA-ER-A193	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7982
p.S555F	DO47368	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7982
p.S347F	DO220913	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.9093
p.R336G	DO219883	SKCA	ICGC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.P335L	DO229453	SKCA	ICGC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.M551V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.M551V	ACH-002026	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.M551V	SNG-M	endometrium	COSMIC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.E545K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	553:557	Mutation blocking phosphorylation signal	0.5556
p.M341V	ACH-001164	Sarcoma	CCLE	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.25
p.A350S	RCC-ER	kidney	COSMIC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2778
p.C349S	RCC-ER	kidney	COSMIC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.R566G	DG-75	haematopoietic and lymphoid tissue	COSMIC	PPSST	DEG_SPOP_SBC_1	553:557	Mutation blocking phosphorylation signal	0.5278
p.N349S	NCI-H1048	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.N349S	IGR-37	skin	COSMIC	ASTSS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056

Kaplan plot for PHLDB2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHLDB2

UniProt ID: Q86SQ0

Entrez ID: 90102

Protein name: Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PHLDB2 in