DegronMD - Q86UK7(ZNF598)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A730T	TCGA-A5-A2K5	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.6028
p.A724T	TCGA-AX-A2HD	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.1944
p.P446L	TCGA-D3-A5GU	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2222
p.P446L	DO47584	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2222
p.P446S	TCGA-D3-A5GU	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2222
p.P464H	TCGA-F1-6874	STAD	TCGA	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0556
p.T735I	DO233804	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.2778
p.P464T	DO229018	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0556
p.Q732L	DO52318	LIHC	ICGC	PATTT	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7765
p.G733D	DO219144	LUSC	ICGC	PATTT	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7198
p.Q732R	DO48944	PBCA	ICGC	PATTT	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7329
p.S455I	DO229250	THCA	ICGC	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.3056
p.S457N	DO40825	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.25
p.S455G	DO42023	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.3056
p.S455G	ACH-001031	Rhabdoid	CCLE	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.3056
p.F720S	DO41331	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	729:733	Mutation blocking phosphorylation signal	0.5278
p.K441N	SIDM00596	Endometrial Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation substituting flanking lysine	0.1944
p.S454R	ACH-000687	Lymphoma	CCLE	ASTSS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7427

Kaplan plot for ZNF598 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF598

UniProt ID: Q86UK7

Entrez ID: 90850

Protein name: E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF598 in