DegronMD - Q86V40(TRABD2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R380S	TCGA-06-0650	GBM	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation substituting flanking lysine	0.3611
p.R380S	DO12628	GBM	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation substituting flanking lysine	0.3611
p.R371W	TCGA-06-0744	GBM	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R371W	TCGA-AA-3492	COAD	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R371W	TCGA-CG-5723	STAD	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R371W	DO8224	COAD	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R371W	DO11860	GBM	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R371W	DO38376	STAD	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R376W	TCGA-27-2519	GBM	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R376W	DO12790	GBM	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.K372E	TCGA-A7-A6VX	BRCA	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7022
p.K372E	DO50019	BRCA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7022
p.E367K	TCGA-BH-A0B4	BRCA	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.E367K	TCGA-D1-A103	UCEC	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.E367K	TCGA-WE-A8K5	SKCM	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.E367K	DO4617	BRCA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.E367K	DO51282	SKCM	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.E367K	DO42312	UCEC	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.R384W	TCGA-BH-A0HK	BRCA	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.R384W	DO5717	BRCA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.R376Q	TCGA-D1-A1NY	UCEC	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R376Q	DO42512	UCEC	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R374W	TCGA-D6-6825	HNSC	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R374W	DO14630	HNSC	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R371Q	TCGA-MY-A913	CESC	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	TCGA-VQ-A8P2	STAD	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	DO49980	CESC	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	DO222843	MELA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	DO51761	STAD	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	ACH-000979	Prostate Cancer	CCLE	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	ACH-000995	Leukemia	CCLE	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	DU-145	prostate	COSMIC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R371Q	Jurkat	haematopoietic and lymphoid tissue	COSMIC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7329
p.R384Q	TCGA-VS-A9UJ	CESC	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.R384Q	DO219735	CESC	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.R384Q	DO227692	COCA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.R382Q	TCGA-W3-A825	SKCM	TCGA	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1944
p.R382Q	DO220875	MELA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1944
p.R382Q	DO222875	MELA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1944
p.R382Q	DO51272	SKCM	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1944
p.P381L	DO229353	LAML	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2222
p.P381L	DO52365	LUSC	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2222
p.P381T	DO229019	LICA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2222
p.Q368K	DO229038	LICA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation blocking phosphorylation signal	0.75
p.S359N	DO222632	MELA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.0556
p.T362A	DO229264	THCA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.R379Q	DO229264	THCA	ICGC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2778
p.R370W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R370W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.R370W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.8634
p.P382H	SIDM00500	Colorectal Carcinoma	GDSC	TRPTLSTIF	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1944

Kaplan plot for TRABD2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRABD2A

UniProt ID: Q86V40

Entrez ID: 129293

Protein name: Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRABD2A in