DegronMD - Q86VV8(RTTN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G297S	TCGA-06-5416	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.G297S	DO10880	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.D329Y	TCGA-73-4659	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.D329Y	DO24467	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.R324I	TCGA-77-7140	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1111
p.R324I	DO26455	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1111
p.Q328H	TCGA-A5-A0G2	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.Q328H	DO41235	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.R312W	TCGA-AP-A059	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	DO41361	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	ACH-000789	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	NCI-H810	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G317W	TCGA-B0-4698	KIRC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.G317W	DO20368	KIRC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.G327D	TCGA-BA-A6DJ	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.G327D	DO52034	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.G320D	TCGA-BR-4184	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.G320D	DO38328	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.R312Q	TCGA-BS-A0UM	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312Q	DO43065	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G297D	TCGA-CA-6717	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.G297D	DO8264	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.S301F	TCGA-CN-5360	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1944
p.S301F	DO14662	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1944
p.R318P	TCGA-EA-A3HU	CESC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1111
p.R318P	DO6320	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1111
p.S338R	TCGA-HQ-A5NE	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.S338R	DO51900	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.T319I	TCGA-NC-A5HH	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.T319I	DO219187	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.P304S	TCGA-WE-A8K5	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.P304S	DO51282	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R318S	DO229037	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1111
p.Q328K	DO229045	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.Q328E	DO224610	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.S340I	SIDM00303	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.S340I	ACH-000584	Ovarian Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.S340I	JHOS-4	ovary	COSMIC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.Q302P	SIDM00188	Kidney Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2222
p.Q302P	SIDM01711	Non-Cancerous	GDSC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2222
p.Q302P	ACH-002350	Non-Cancerous	CCLE	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2222
p.G307E	SIDM00660	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6087
p.G307E	ACH-000985	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6087
p.G307E	LS-411N	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6087
p.V344A	SIDM00217	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1111
p.V344A	ACH-000999	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1111
p.V344A	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1111
p.W330C	ACH-000820	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.V312A	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.T314I	NCI-H69	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTTN

UniProt ID: Q86VV8

Entrez ID: 25914

Protein name: Rotatin

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RTTN in