DegronMD - Q86VV8(RTTN)

FUNCTION: Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. {ECO:0000269|PubMed:22939636}.

GO - Biological processes (BP): centriole-centriole cohesion [GO:0010457]; centriole replication [GO:0007099]; ciliary basal body organization [GO:0032053]; determination of left/right symmetry [GO:0007368]

GO - Molecular function (MF):

GO - Cellular component (CC): centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PGSSS	DEG_SPOP_SBC_1	SPOP	Rotatin	306:310	More..
AASSS	DEG_SPOP_SBC_1	SPOP	Rotatin	332:336	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G307E	SIDM00660	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6087
p.G307E	ACH-000985	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6087
p.G307E	LS-411N	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6087
p.R312W	TCGA-AP-A059	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	DO41361	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	ACH-000789	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312W	NCI-H810	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312Q	TCGA-BS-A0UM	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.R312Q	DO43065	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.S338R	TCGA-HQ-A5NE	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.S338R	DO51900	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.P304S	TCGA-WE-A8K5	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.P304S	DO51282	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.W330C	ACH-000820	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.V312A	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.D329Y	TCGA-73-4659	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.D329Y	DO24467	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.25
p.Q328H	TCGA-A5-A0G2	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222
p.Q328H	DO41235	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2222

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Kaplan plot for RTTN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTTN

UniProt ID: Q86VV8

Entrez ID: 25914

Protein name: Rotatin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTTN in