DegronMD - Q86VZ4(LRP11)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P408S	TCGA-3N-A9WD	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0833
p.P417L	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7582
p.P417L	ACH-000675	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7582
p.P417L	NCI-H1734	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7582
p.D418Y	SIDM00213	Thyroid Gland Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.6214
p.D418Y	FTC-133	thyroid	COSMIC	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.6214
p.E409Q	ACH-001412	Bladder Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons