DegronMD - Q86W24(NLRP14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G14W	TCGA-18-3417	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.G14W	DO26584	LUSC	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.F13L	TCGA-35-5375	LUAD	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.F13L	DO25290	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.P11S	TCGA-39-5016	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.P11S	TCGA-Z2-AA3S	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.P11S	DO26701	LUSC	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.P11S	DO51302	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1944
p.S5L	TCGA-55-7576	LUAD	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S5L	TCGA-EE-A20C	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S5L	TCGA-W3-A825	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S5L	DO24431	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S5L	DO222775	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S5L	DO47665	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S5L	DO51272	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.F9L	TCGA-AA-A00N	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.25
p.F9L	DO9876	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.25
p.S7Y	TCGA-BS-A0UF	UCEC	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.S7Y	DO41488	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.F10C	TCGA-BS-A0UF	UCEC	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2222
p.F10C	DO41488	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2222
p.D3Y	TCGA-CA-6718	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6214
p.D3Y	DO7801	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6214
p.S6L	TCGA-D9-A6EC	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S6L	DO50291	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.D3N	TCGA-EE-A2GC	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.5821
p.D3N	DO37839	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.5821
p.S4L	TCGA-QB-A6FS	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.S4L	DO48654	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7667
p.F13C	TCGA-VR-A8EQ	ESCA	TCGA	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.L16I	DO232224	PBCA	ICGC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.S4T	SIDM00698	Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6005
p.S4T	SIDM00467	Acute Myeloid Leukemia	GDSC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6005
p.D12H	SIDM00414	Bladder Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.D12H	ACH-000545	Bladder Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.D12H	VM-CUB-1	urinary tract	COSMIC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.D3G	SIDM00954	Breast Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6087
p.A2E	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7701
p.A2E	ACH-000053	Lymphoma	CCLE	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7701
p.A2E	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7701

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NLRP14

UniProt ID: Q86W24

Entrez ID: 338323

Protein name: NACHT, LRR and PYD domains-containing protein 14 (Nucleotide-binding oligomerization domain protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NLRP14 in