DegronMD - Q86W28(NLRP8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S22Y	TCGA-06-5416	GBM	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.S22Y	DO10880	GBM	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.W27C	TCGA-44-4112	LUAD	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.W27C	DO229022	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.W27C	DO26032	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.S15L	TCGA-A2-A0CX	BRCA	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.S15L	DO2755	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.W27L	TCGA-D3-A3CE	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.W27L	DO37405	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.P13L	TCGA-DA-A1I1	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P13L	TCGA-YD-A89C	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P13L	DO37966	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P13L	DO219501	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P13L	SIDM01161	Other Sarcomas	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P13L	ACH-001274	Sarcoma	CCLE	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P13L	SW982	soft tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.P11L	TCGA-ER-A19P	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.P11L	DO47623	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.H20R	TCGA-F5-6814	READ	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.25
p.H20R	DO36556	READ	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.25
p.P13S	TCGA-W3-AA1Q	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6752
p.P13S	DO219487	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6752
p.P25L	DO227709	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.P25L	DO229010	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.P25L	DO229013	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.P25L	DO229016	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.P25L	DO229003	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.P25L	DO229005	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.F14I	DO233293	NACA	ICGC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6304
p.S22P	SIDM00578	Neuroblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.S22P	ACH-000804	Neuroblastoma	CCLE	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.I12L	SIDM00475	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM00523	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM00821	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM01051	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM00670	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM00876	Non-Cancerous	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM00877	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.I12L	SIDM01696	Mesothelioma	GDSC	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.P6L	ACH-001814	Bone Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NLRP8

UniProt ID: Q86W28

Entrez ID: 126205

Protein name: NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NLRP8 in