DegronMD - Q86XK2(FBXO11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A112V	TCGA-AX-A06F	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.A112V	DO233764	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.A112V	DO41752	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.R133P	TCGA-B5-A0K2	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.R133P	DO43835	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.A134E	DO229022	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.N129S	DO38404	STAD	ICGC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.25
p.N117D	SIDM00962	Chronic Myelogenous Leukemia	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.N117D	ACH-000432	Leukemia	CCLE	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.N117D	BV-173	haematopoietic and lymphoid tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.T126S	SIDM00798	Rhabdomyosarcoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM01117	Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM00633	Breast Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM00529	Breast Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM00849	Kidney Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM00844	Burkitt's Lymphoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM01140	Ovarian Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM00720	Mesothelioma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM01173	Rhabdomyosarcoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM01664	Prostate Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005
p.T126S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6005

Kaplan plot for FBXO11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO11

UniProt ID: Q86XK2

Entrez ID: 80204

Protein name: F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO11 in