DegronMD - Q86YD5(LDLRAD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A246V	TCGA-B5-A3FC	UCEC	TCGA	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A246V	SIDM01609	Endometrial Carcinoma	GDSC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A246V	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.P276L	TCGA-BR-4184	STAD	TCGA	PPPY	ITCH	275:278	Mutation altering degron motif	0.7582
p.A269V	TCGA-BR-7851	STAD	TCGA	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A269V	TCGA-BR-7851	STAD	TCGA	PPPY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.A269V	SIDM00789	Colorectal Carcinoma	GDSC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A269V	SIDM00789	Colorectal Carcinoma	GDSC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.A269V	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A269V	ACH-000997	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.A269V	HCT-15	large intestine	COSMIC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A269V	HCT-15	large intestine	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.S251L	TCGA-E6-A1LX	UCEC	TCGA	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1944
p.P276S	TCGA-EE-A2MS	SKCM	TCGA	PPPY	ITCH	275:278	Mutation altering degron motif	0.6752
p.A250V	TCGA-EO-A3B0	UCEC	TCGA	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1667
p.S260F	TCGA-FR-A726	SKCM	TCGA	PPSY	ITCH	256:259	Mutation rewiring degron network	0.3056
p.G288W	DO222641	BTCA	ICGC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0556
p.G288R	DO229047	LICA	ICGC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0556
p.D262Y	DO46606	OV	ICGC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.25
p.E273K	DO228138	PBCA	ICGC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.2778
p.E251K	DO232761	PBCA	ICGC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1944
p.P266S	DO37567	SKCM	ICGC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1389
p.P266S	DO37567	SKCM	ICGC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0833
p.S250F	DO48665	SKCM	ICGC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1667
p.R284H	DO38599	STAD	ICGC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.1667
p.A259V	DO38711	STAD	ICGC	PPSY	ITCH	256:259	Mutation altering degron motif	0.6936
p.A259V	HCT-15	large intestine	COSMIC	PPSY	ITCH	256:259	Mutation altering degron motif	0.6936
p.P266L	DO38328	STAD	ICGC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1389
p.P266L	DO38328	STAD	ICGC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0833
p.Q287L	SIDM01071	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0833
p.Q287L	ACH-000515	Lung Cancer	CCLE	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0833
p.Q287L	HCC-33	lung	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.0833
p.D281N	SIDM00589	Oral Cavity Carcinoma	GDSC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.25
p.D281N	ACH-000778	Head and Neck Cancer	CCLE	PPPY	ITCH	275:278	Mutation rewiring degron network	0.25
p.D281N	HSC-3	upper aerodigestive tract	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.25
p.P256S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	256:259	Mutation altering degron motif	0.6752
p.P256S	ACH-002059	Leukemia	CCLE	PPSY	ITCH	256:259	Mutation altering degron motif	0.6752
p.P256S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	256:259	Mutation altering degron motif	0.6752
p.G254D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.2778
p.G254D	ACH-002222	Leukemia	CCLE	PPSY	ITCH	256:259	Mutation rewiring degron network	0.2778
p.G254D	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.2778
p.P274S	SIDM01059	Melanoma	GDSC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.3056
p.P274S	ACH-000915	Skin Cancer	CCLE	PPPY	ITCH	275:278	Mutation rewiring degron network	0.3056
p.P274S	IPC-298	skin	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.3056
p.P246S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.0556
p.A251V	MEG-01	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1944
p.P282L	HuO-3N1	bone	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.2222
p.P282L	JHH-1	liver	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.2222
p.D271N	HSC-3	upper aerodigestive tract	COSMIC	PPPY	ITCH	275:278	Mutation rewiring degron network	0.2222
p.Q277L	HCC-33	lung	COSMIC	PPPY	ITCH	275:278	Mutation altering degron motif	0.7765
p.P264S	IPC-298	skin	COSMIC	PPSY	ITCH	256:259	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LDLRAD3

UniProt ID: Q86YD5

Entrez ID: 143458

Protein name: Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LDLRAD3 in