MARCHF9
UniProt ID: Q86YJ5
Entrez ID: 92979
Protein name: E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and the...
FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17174307}.
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GO - Biological processes (BP):
protein ubiquitination [GO:0016567]...
protein ubiquitination [GO:0016567]
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GO - Molecular function (MF):
transferase activity [GO:0016740]; zinc ion binding [GO:0008270]...
transferase activity [GO:0016740]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802]...
Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802]
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MARCHF9
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Kaplan plot for MARCHF9 in
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*NOTE: the Kaplan plots were collected from OncoLnc