DegronMD - Q86YQ8(CPNE8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P546Q	TCGA-18-3412	LUSC	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.2222
p.R542L	TCGA-49-AARE	LUAD	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.R542L	SIDM01316	Ewing's Sarcoma	GDSC	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.R542L	ACH-000041	Bone Cancer	CCLE	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.A549V	TCGA-AA-A010	COAD	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.A549V	TCGA-AD-A5EJ	COAD	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.Q563K	TCGA-AG-A002	READ	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.0556
p.Q563K	TCGA-AP-A056	UCEC	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.0556
p.P548L	TCGA-AP-A0LM	UCEC	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.2778
p.Q561H	TCGA-AX-A2HG	UCEC	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.A549E	TCGA-D1-A16Y	UCEC	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.R542Q	TCGA-EY-A1GI	UCEC	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.R542Q	SIDM00516	Melanoma	GDSC	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.R542Q	ACH-002166	Skin Cancer	CCLE	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.R542Q	MZ7-mel	skin	COSMIC	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.R542P	TCGA-MV-A51V	BLCA	TCGA	PPPY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.T557P	TCGA-R6-A8W5	ESCA	TCGA	PPPY	ITCH	550:553	Mutation blocking phosphorylation signal	0.6667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons