DegronMD - Q86YZ3(HRNR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R506Q	TCGA-17-Z016	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1944
p.R506Q	TCGA-D7-A6EY	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1944
p.R506Q	DO50118	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1944
p.P2837S	TCGA-55-A4DG	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.3056
p.P2837S	DO26337	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.3056
p.P2837S	DO232761	PBCA	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.3056
p.R525C	TCGA-A5-A1OF	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.R525C	DO42568	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.R525C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.R525C	ACH-000953	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.R525C	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.G512D	TCGA-BT-A20J	BLCA	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.6087
p.G512D	DO457	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.6087
p.S2823I	TCGA-DD-A1E9	LIHC	TCGA	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0833
p.S2823I	DO22890	LIHC	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0833
p.A511V	TCGA-DF-A2KU	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.5825
p.A511V	DO223286	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.5825
p.G2822E	TCGA-EE-A182	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0556
p.G2822E	DO37814	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0556
p.G504D	TCGA-FW-A3R5	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.G504D	DO37406	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.G504S	TCGA-FW-A3R5	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.G504S	DO37406	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.S514T	TCGA-O2-A52Q	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.6005
p.S514T	DO219219	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.6005
p.S515Y	TCGA-ZS-A9CE	LIHC	TCGA	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.712
p.S515Y	DO49720	LIHC	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.712
p.S2823T	DO222623	BTCA	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0833
p.E505K	DO218139	BTCA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1667
p.Y517C	DO229010	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.7222
p.Y517C	DO229016	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.7222
p.Y517C	DO229003	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.7222
p.Y517C	DO229489	LAML	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.7222
p.Y517C	DO228941	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.7222
p.G523D	DO10840	ESAD	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1111
p.Y517D	DO234293	ESAD	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.7222
p.R525H	DO217822	GACA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.R525H	DO34264	PACA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.R506L	DO233648	GACA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1944
p.Q507H	DO228943	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.Q507H	DO229051	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.Q507H	DO229062	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.A511S	DO228960	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7588
p.A511S	DO229052	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7588
p.A511S	DO231475	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7588
p.Q519P	DO230990	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.G2822R	DO222363	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0556
p.P2832S	DO222837	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation altering degron motif	0.6752
p.R2845S	DO233973	THCA	ICGC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.0833
p.G518V	SIDM00683	Prostate Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.25
p.G518V	ACH-000977	lymph node	CCLE	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.25
p.G518V	LNCaP-Clone-FGC	prostate	COSMIC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.25
p.T2835I	SIDM00327	Hodgkin's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation altering degron motif	0.7078
p.T2835I	ACH-000754	Lymphoma	CCLE	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation altering degron motif	0.7078
p.T2835I	L-428	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation altering degron motif	0.7078
p.S2824Y	SIDM00049	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.1111
p.S2824Y	ACH-002233	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.1111
p.S2824Y	DIFI	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	2832:2836	Mutation rewiring degron network	0.1111
p.S522F	SIDM00591	Oral Cavity Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.S522F	ACH-002045	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.S522F	HO-1-u-1	upper aerodigestive tract	COSMIC	AGSSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HRNR

UniProt ID: Q86YZ3

Entrez ID: 388697

Protein name: Hornerin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HRNR in