RNF135
UniProt ID: Q8IUD6
Entrez ID: 84282
Protein name: E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:3100653...
FUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}.
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GO - Biological processes (BP):
antiviral innate immune response [GO:0140374]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; protein homooligomerization [GO:0051260]; protein K63-linked ubiquitination [GO:0070534]; protein poly...
antiviral innate immune response [GO:0140374]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; protein homooligomerization [GO:0051260]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of innate immune response [GO:0045088]; RIG-I signaling pathway [GO:0039529]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RIG-I binding [GO:0039552]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]...
identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; RIG-I binding [GO:0039552]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]...
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]
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RNF135
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*NOTE: the Kaplan plots were collected from OncoLnc