RIOX2
UniProt ID: Q8IUF8
Entrez ID: 84864
Protein name: Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.-) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protei...
FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}.
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GO - Biological processes (BP):
histone H3-K36 demethylation [GO:0070544]; histone H3-K4 demethylation [GO:0034720]; ribosome biogenesis [GO:0042254]...
histone H3-K36 demethylation [GO:0070544]; histone H3-K4 demethylation [GO:0034720]; ribosome biogenesis [GO:0042254]
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GO - Molecular function (MF):
2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; histone H3-methyl-lysine-4 demethylase activity [GO:0032453]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ...
2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; histone H3-methyl-lysine-4 demethylase activity [GO:0032453]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]...
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]
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RIOX2
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Kaplan plot for RIOX2 in
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*NOTE: the Kaplan plots were collected from OncoLnc