DegronMD - Q8IV36(HID1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A284T	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.1389
p.A284T	DO10880	GBM	ICGC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.1389
p.T681M	TCGA-AA-3877	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation blocking phosphorylation signal	0.5556
p.T681M	DO7855	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation blocking phosphorylation signal	0.5556
p.E278K	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.3056
p.E278K	DO41361	UCEC	ICGC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.3056
p.E278K	SIDM01059	Melanoma	GDSC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.3056
p.E278K	IPC-298	skin	COSMIC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.3056
p.S675T	TCGA-AX-A2HD	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation blocking phosphorylation signal	0.7222
p.S675T	DO42608	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation blocking phosphorylation signal	0.7222
p.Y268C	TCGA-CG-4305	STAD	TCGA	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.1389
p.Y268C	DO38823	STAD	ICGC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.1389
p.G265R	TCGA-D1-A103	UCEC	TCGA	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.0556
p.G265R	DO42312	UCEC	ICGC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.0556
p.G265W	TCGA-ER-A19B	SKCM	TCGA	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.0556
p.G265W	TCGA-FS-A1ZM	SKCM	TCGA	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.0556
p.G265W	DO37731	SKCM	ICGC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.0556
p.G265W	DO47491	SKCM	ICGC	DYR	CBL_MET	275:277	Mutation rewiring degron network	0.0556
p.R277W	TCGA-FI-A2D0	UCEC	TCGA	DYR	CBL_MET	275:277	Mutation altering degron motif	0.8634
p.R277W	DO43891	UCEC	ICGC	DYR	CBL_MET	275:277	Mutation altering degron motif	0.8634
p.G676V	TCGA-IB-7651	PAAD	TCGA	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.25
p.G676V	DO46657	PAAD	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.25
p.R668Q	DO50533	BOCA	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.3056
p.E683Q	DO225354	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.0556
p.G676E	DO233292	NACA	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.25
p.E665K	DO229456	SKCA	ICGC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation rewiring degron network	0.2222
p.S670P	ACH-000770	Leukemia	CCLE	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.6752
p.S670P	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	669:673	Mutation altering degron motif	0.6752

Kaplan plot for HID1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HID1

UniProt ID: Q8IV36

Entrez ID: 283987

Protein name: Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HID1 in