DegronMD - Q8IVS8(GLYCTK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G453V	TCGA-50-5942	LUAD	TCGA	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.G453V	DO228976	LICA	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.G453V	DO23641	LUAD	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0556
p.D452N	TCGA-C5-A8XH	CESC	TCGA	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0833
p.D452N	DO49898	CESC	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.0833
p.L428M	TCGA-EE-A2GT	SKCM	TCGA	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1389
p.L428M	DO37946	SKCM	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1389
p.P438S	TCGA-EY-A1GK	UCEC	TCGA	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5641
p.P438S	DO42985	UCEC	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5641
p.W437L	TCGA-GD-A3OS	BLCA	TCGA	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5904
p.W437L	DO598	BLCA	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5904
p.W437L	DO229028	LICA	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5904
p.P441S	DO222842	COCA	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.5641
p.P438L	DO234361	ESAD	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.6471
p.P438L	SIDM01398	Melanoma	GDSC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation altering degron motif	0.6471
p.L434F	DO229027	LICA	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.3056
p.A427S	DO229035	LICA	ICGC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.1111
p.A432V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25
p.A432V	ACH-000980	Lung Cancer	CCLE	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25
p.A432V	NCI-H1155	lung	COSMIC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25
p.A432T	SIDM00785	Acute Myeloid Leukemia	GDSC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25
p.A432T	KG-1	haematopoietic and lymphoid tissue	COSMIC	RRWPLGPID	DEG_APCC_DBOX_1	435:443	Mutation rewiring degron network	0.25

Kaplan plot for GLYCTK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLYCTK

UniProt ID: Q8IVS8

Entrez ID: 132158

Protein name: Glycerate kinase (EC 2.7.1.31) (HBeAg-binding protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLYCTK in