DegronMD - Q8IWY8(ZSCAN29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R117C	TCGA-2W-A8YY	CESC	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.2222
p.T122P	TCGA-A5-A0GA	UCEC	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation altering degron motif	0.8142
p.R134W	TCGA-AZ-6601	COAD	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1111
p.R134W	ACH-001991	Primary	CCLE	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1111
p.Q135L	TCGA-B0-5705	KIRC	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.0833
p.E119D	TCGA-BH-A1FN	BRCA	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.2778
p.G113W	TCGA-EE-A181	SKCM	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1111
p.E115K	TCGA-FD-A6TC	BLCA	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1667
p.S132R	TCGA-VQ-AA64	STAD	TCGA	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation blocking phosphorylation signal	0.6111
p.E114K	DO49755	BLCA	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1389
p.E118D	DO5214	BRCA	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.25
p.R116C	DO223732	CESC	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1944
p.R133W	DO8119	COAD	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1389
p.T121I	DO233073	GACA	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation altering degron motif	0.7078
p.Q134L	DO19913	KIRC	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1111
p.P122T	DO229019	LICA	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation altering degron motif	0.7031
p.S131R	DO228893	LICA	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1944
p.S131R	DO222381	STAD	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1944
p.R133L	DO48689	LIRI	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1389
p.G112W	DO37444	SKCM	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation substituting flanking lysine	0.1944
p.V115L	DO229208	THCA	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1667
p.T121P	DO43763	UCEC	ICGC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation altering degron motif	0.7031
p.R134L	SIDM00845	Burkitt's Lymphoma	GDSC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.1111
p.P124L	SIDM00845	Burkitt's Lymphoma	GDSC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation altering degron motif	0.6471
p.K112E	SIDM01652	Non-Cancerous	GDSC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation substituting flanking lysine	0.1944
p.K112E	SIDM00187	Kidney Carcinoma	GDSC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation substituting flanking lysine	0.1944
p.E111K	BE-13	haematopoietic and lymphoid tissue	COSMIC	MTPPKS	DEG_SCF_FBW7_1	121:126	Mutation rewiring degron network	0.0556

Kaplan plot for ZSCAN29 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZSCAN29

UniProt ID: Q8IWY8

Entrez ID: 146050

Protein name: Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZSCAN29 in