SLF2
UniProt ID: Q8IX21
Entrez ID: 55719
Protein name: SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA...
FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). {ECO:0000269|PubMed:25931565}.
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GO - Biological processes (BP):
cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of pr...
cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]
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GO - Molecular function (MF):
protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]...
protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]
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GO - Cellular component (CC):
chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]...
chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]
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SLF2
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*NOTE: the Kaplan plots were collected from OncoLnc