DegronMD - Q8IXQ4(GPALPP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A34D	TCGA-B5-A3FA	UCEC	TCGA	PPNY	ITCH	36:39	Mutation rewiring degron network	0.2778
p.A34D	DO52402	UCEC	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.2778
p.V30A	TCGA-VQ-A924	STAD	TCGA	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1667
p.V30A	DO51795	STAD	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1667
p.S46L	DO225215	BRCA	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1389
p.S46L	DO227836	BRCA	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1389
p.T46A	DO10244	COAD	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1389
p.D44Y	DO229031	LICA	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1944
p.S28G	DO51474	PACA	ICGC	PPNY	ITCH	36:39	Mutation blocking phosphorylation signal	0.5556
p.R41I	DO41235	UCEC	ICGC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.2778
p.S42N	SIDM00422	Hodgkin's Lymphoma	GDSC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.25
p.S42N	ACH-001203	Lymphoma	CCLE	PPNY	ITCH	36:39	Mutation rewiring degron network	0.25
p.S42N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.25
p.P36S	ACH-000763	Myeloma	CCLE	PPNY	ITCH	36:39	Mutation altering degron motif	0.6752
p.P36S	MM1S	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	36:39	Mutation altering degron motif	0.6752
p.S40N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.3056
p.P39T	LP-1	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	36:39	Mutation altering degron motif	0.7031
p.G30D	KM12	large intestine	COSMIC	PPNY	ITCH	36:39	Mutation rewiring degron network	0.1667

Kaplan plot for GPALPP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPALPP1

UniProt ID: Q8IXQ4

Entrez ID: 55425

Protein name: GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPALPP1 in