DegronMD - Q8IXQ5(KLHL7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R288I	TCGA-AG-A002	READ	TCGA	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.2222
p.Q302R	TCGA-B0-5098	KIRC	TCGA	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1111
p.R294H	TCGA-CN-6023	HNSC	TCGA	DYR	CBL_MET	292:294	Mutation altering degron motif	0.8244
p.R294H	ACH-001131	Skin Cancer	CCLE	DYR	CBL_MET	292:294	Mutation altering degron motif	0.8244
p.G300A	TCGA-HU-A4GX	STAD	TCGA	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1667
p.K289N	TCGA-MF-A522	LUSC	TCGA	DYR	CBL_MET	292:294	Mutation substituting flanking lysine	0.3611
p.R285T	TCGA-XF-AAMG	BLCA	TCGA	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1389
p.P300Q	DO28923	OV	ICGC	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1667
p.V289A	DO51761	STAD	ICGC	DYR	CBL_MET	292:294	Mutation substituting flanking lysine	0.3611
p.V284M	SW48	large intestine	COSMIC	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.1111
p.C283Y	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	292:294	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons