DegronMD - Q8IY22(CMIP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V4F	DO228971	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7068
p.P7R	DO229032	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7512
p.Q3R	DO45153	LIRI	ICGC	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7329
p.S7L	DO37424	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.8778
p.S16F	DO51277	SKCM	ICGC	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.S7A	ACH-000431	Lung Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.87
p.S5N	ACH-000979	Prostate Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7069
p.P6L	LU-139	lung	COSMIC	VTSSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7582

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons