DegronMD - Q8IYL3(C1orf174)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P210S	TCGA-AX-A1CE	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.6752
p.P210S	DO42280	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.6752
p.A211V	TCGA-AX-A2HD	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5825
p.A211V	DO233089	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5825
p.A211V	DO42608	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5825
p.E203Q	TCGA-DK-A6B6	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.E203Q	DO48576	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.A38V	TCGA-DU-6401	LGG	TCGA	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.3056
p.A38V	DO22490	LGG	ICGC	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.3056
p.R25M	DO225273	BRCA	ICGC	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1111
p.T36K	DO228986	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7306
p.T36K	DO229018	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7306
p.S47Y	DO229008	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.S37C	DO48709	LIRI	ICGC	AGSTS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.8652
p.R220K	SIDM00587	Biliary Tract Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1667
p.R220K	ACH-000976	Bile Duct Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons