DegronMD - Q8IZ20(ZNF683)

ZNF683

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A486T	TCGA-AP-A1DV	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.0556
p.D501E	TCGA-VS-A9UV	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.3056
p.S510R	DO229019	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.0556
p.D490E	DO229031	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1667
p.T499K	DO229045	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation altering degron motif	0.7306
p.S498L	DO42280	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation altering degron motif	0.7667
p.A506T	DO43186	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1667
p.K503N	SIDM00087	Plasma Cell Myeloma	GDSC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation substituting flanking lysine	0.3611
p.K503N	SIDM00971	Breast Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation substituting flanking lysine	0.3611
p.S510G	SIDM01045	Endometrial Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.0556
p.S510G	EN	endometrium	COSMIC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.0556
p.S490G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1667
p.S490G	EN	endometrium	COSMIC	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1667
p.G499A	ACH-001277	Sarcoma	CCLE	VSSTS	DEG_SPOP_SBC_1	496:500	Mutation altering degron motif	0.754

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*NOTE: the Kaplan plots were collected from OncoLnc