H1-8
UniProt ID: Q8IZA3
Entrez ID: 132243
Protein name: Histone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in...
FUNCTION: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
chromosome condensation [GO:0030261]; meiotic cell cycle [GO:0051321]; negative regulation of DNA recombination [GO:0045910]; negative regulation of stem cell differentiation [GO:2000737]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; regulation of DNA methylation [GO:004403...
chromosome condensation [GO:0030261]; meiotic cell cycle [GO:0051321]; negative regulation of DNA recombination [GO:0045910]; negative regulation of stem cell differentiation [GO:2000737]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; regulation of DNA methylation [GO:0044030]
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GO - Molecular function (MF):
double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]...
double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleosome [GO:0000786]; nucleus [GO:0005634]
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H1-8
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*NOTE: the Kaplan plots were collected from OncoLnc