DegronMD - Q8IZD9(DOCK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1739N	TCGA-AY-A54L	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.3056
p.S1739N	DO44091	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.3056
p.S1753F	TCGA-EE-A181	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0833
p.S1753F	DO37444	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0833
p.S1735L	TCGA-FW-A3R5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1944
p.S1735L	DO37406	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1944
p.P1740H	TCGA-GN-A26A	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7694
p.P1740H	DO37861	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7694
p.V1730I	DO233146	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0556
p.V1730F	DO228948	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0556
p.A1738S	DO229026	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.2778
p.V1732F	DO229037	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1111
p.S1734F	SIDM00216	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.S1734F	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.S1734F	SNU-175	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.S1736F	SIDM01175	Other Sarcomas	GDSC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.2222
p.S1736F	ACH-002309	Sarcoma	CCLE	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.2222
p.S1736F	SW684	soft tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.2222
p.S1742F	SIDM00007	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7982
p.S1742F	ACH-001550	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7982
p.S1742F	MCC13	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7982
p.T1748I	ACH-001369	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.2222
p.Q1737K	ACH-001845	Bile Duct Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25

Kaplan plot for DOCK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK3

UniProt ID: Q8IZD9

Entrez ID: 1795

Protein name: Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK3 in