DegronMD - Q8IZJ3(CPAMD8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1769T	SIDM00155	Head and Neck Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.2778
p.P1769T	SIDM00790	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.2778
p.P1769T	SIDM00900	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.2778
p.D1774N	SIDM00879	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1389
p.D1774N	SIDM01257	Hepatocellular Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1389
p.A1755E	SIDM00085	Glioma	GDSC	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1111
p.A1755E	ACH-000655	Brain Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1111
p.S1773P	ACH-000982	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1667
p.S1773P	ACH-001345	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1763:1767	Mutation rewiring degron network	0.1667

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons