DegronMD - Q8IZW8(TNS4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S303T	TCGA-BR-6452	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1111
p.S303T	DO38404	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1111
p.R305S	TCGA-BR-8363	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1667
p.R305S	DO47837	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1667
p.S324A	TCGA-EW-A2FR	BRCA	TCGA	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.0833
p.S324A	DO5396	BRCA	ICGC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.0833
p.A311T	DO6600	CLLE	ICGC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation altering degron motif	0.7139
p.P310S	SIDM00545	Melanoma	GDSC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	ACH-000964	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	ACH-000987	Skin Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	ACH-001127	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	Mewo	skin	COSMIC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.P310S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons