DegronMD - Q8N114(SHISA5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y159S	TCGA-A5-A2K5	UCEC	TCGA	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.P166L	TCGA-A6-6653	COAD	TCGA	PPSY	ITCH	166:169	Mutation altering degron motif	0.7582
p.A157D	TCGA-CG-4305	STAD	TCGA	PPSY	ITCH	166:169	Mutation rewiring degron network	0.0833
p.P166S	TCGA-CQ-A4CB	HNSC	TCGA	PPSY	ITCH	166:169	Mutation altering degron motif	0.6752
p.P162H	TCGA-CV-7434	HNSC	TCGA	PPSY	ITCH	166:169	Mutation rewiring degron network	0.2222
p.P207Q	TCGA-E7-A6MD	BLCA	TCGA	PPAY	ITCH	206:209	Mutation altering degron motif	0.7035
p.Q161K	TCGA-ER-A19P	SKCM	TCGA	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1944
p.A219T	TCGA-G4-6628	COAD	TCGA	PPAY	ITCH	206:209	Mutation rewiring degron network	0.0556
p.A219T	SIDM02016	Colorectal Carcinoma	GDSC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.0556
p.P162S	TCGA-MV-A51V	BLCA	TCGA	PPSY	ITCH	166:169	Mutation rewiring degron network	0.2222
p.P196S	DO48583	BLCA	ICGC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.0556
p.P176Q	DO219015	BLCA	ICGC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1389
p.A208V	DO9698	COAD	ICGC	PPAY	ITCH	206:209	Mutation altering degron motif	0.5825
p.Y160H	DO21679	LAML	ICGC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1667
p.P169T	DO228948	LICA	ICGC	PPSY	ITCH	166:169	Mutation altering degron motif	0.7031
p.P167H	DO229041	LICA	ICGC	PPSY	ITCH	166:169	Mutation altering degron motif	0.7694
p.H179Q	DO229045	LICA	ICGC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.0556
p.A200D	DO229006	LICA	ICGC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.1667
p.P205L	DO47829	STAD	ICGC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.3056
p.M162L	DO42713	UCEC	ICGC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.2222
p.Q163H	DO42665	UCEC	ICGC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.25
p.L209F	DO220916	WT	ICGC	PPAY	ITCH	206:209	Mutation altering degron motif	0.6981
p.A218D	SIDM01134	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.0833
p.Q161E	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1944
p.Q161E	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1944
p.H210R	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.3056
p.H210R	ACH-000937	Leukemia	CCLE	PPAY	ITCH	206:209	Mutation rewiring degron network	0.3056
p.H210R	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.3056
p.P207L	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPAY	ITCH	206:209	Mutation altering degron motif	0.7582
p.S217N	ACH-001369	Ovarian Cancer	CCLE	PPAY	ITCH	206:209	Mutation rewiring degron network	0.1111
p.H179R	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.0556
p.H203R	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.25
p.Y160C	SNU-1040	large intestine	COSMIC	PPSY	ITCH	166:169	Mutation rewiring degron network	0.1667
p.Y214S	DB	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	206:209	Mutation rewiring degron network	0.1944

Kaplan plot for SHISA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHISA5

UniProt ID: Q8N114

Entrez ID: 51246

Protein name: Protein shisa-5 (Putative NF-kappa-B-activating protein 120) (Scotin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHISA5 in