DegronMD - Q8N122(RPTOR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P879L	TCGA-CG-4305	STAD	TCGA	PASST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7582
p.S877F	TCGA-CV-A45Q	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	879:883	Mutation blocking phosphorylation signal	0.7222
p.D891N	TCGA-EE-A2GC	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.D891N	TCGA-W3-A828	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.V882I	DO233944	GACA	ICGC	PASST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7076
p.V871E	DO218848	SKCA	ICGC	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.D884N	DO219477	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	879:883	Mutation blocking phosphorylation signal	0.75
p.S887N	DO229211	THCA	ICGC	PASST	DEG_SPOP_SBC_1	879:883	Mutation blocking phosphorylation signal	0.6667
p.A874V	SIDM00499	Prostate Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.A874V	ACH-000956	Prostate Cancer	CCLE	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.A874V	22RV1	prostate	COSMIC	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.V869M	SIDM00014	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.V869M	LIM1215	large intestine	COSMIC	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.S881P	ACH-000937	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7863
p.S881P	PF-382	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7863
p.I880V	EN	endometrium	COSMIC	PASST	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7076
p.T877M	GDM-1	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	879:883	Mutation blocking phosphorylation signal	0.7222
p.P878S	SK-CO-1	large intestine	COSMIC	PASST	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056

Kaplan plot for RPTOR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPTOR

UniProt ID: Q8N122

Entrez ID: 57521

Protein name: Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPTOR in