DegronMD - Q8N1G2(CMTR1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E58K	TCGA-AP-A1DV	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.E58K	DO43186	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.A45S	TCGA-EO-A22R	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7588
p.A45S	DO42713	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7588
p.P36S	TCGA-FS-A1Z3	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.P36S	DO37635	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0833
p.G42V	DO217844	BRCA	ICGC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.S55G	DO23152	LINC	ICGC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.6111
p.S55G	DO45081	LINC	ICGC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.6111
p.S55N	SIDM00373	Endometrial Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.6111
p.S55N	ACH-000974	Endometrial/Uterine Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.6111
p.S55N	ACH-002026	Endometrial/Uterine Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.6111
p.S55N	SNG-M	endometrium	COSMIC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.6111
p.G59V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0556
p.G59V	ACH-000766	Lung Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0556
p.G59V	NCI-H1648	lung	COSMIC	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0556
p.S51N	ACH-000850	Non-Cancerous	CCLE	ASTTS	DEG_SPOP_SBC_1	45:49	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for CMTR1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CMTR1

UniProt ID: Q8N1G2

Entrez ID: 23070

Protein name: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CMTR1 in