DegronMD - Q8N2Q7(NLGN1)

GO - Biological processes (BP): AMPA glutamate receptor clustering [GO:0097113]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion involved in synapse maturation [GO:0090125]; cellular response to calcium ion [GO:0071277]; chemical synaptic transmission [GO:0007268]; cytoskeletal matrix organization at active zone [GO:0048789]; establishment of protein localization [GO:0045184]; excitatory synapse assembly [GO:1904861]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; maintenance of synapse structure [GO:0099558]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; nervous system development [GO:0007399]; neurexin clustering involved in presynaptic membrane assembly [GO:0097115]; neuronal signal transduction [GO:0023041]; neuron cell-cell adhesion [GO:0007158]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of circadian sleep/wake cycle, wakefulness [GO:0010841]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; postsynaptic specialization assembly [GO:0098698]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; protein targeting [GO:0006605]; receptor localization to synapse [GO:0097120]; regulation of AMPA receptor activity [GO:2000311]; regulation of neuron differentiation [GO:0045664]; regulation of NMDA receptor activity [GO:2000310]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; rhythmic process [GO:0048511]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]; synaptic membrane adhesion [GO:0099560]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; terminal button organization [GO:0072553] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P811H	TCGA-78-7155	LUAD	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.0833
p.P811H	TCGA-DJ-A2QB	THCA	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.0833
p.P793S	TCGA-B5-A11E	UCEC	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1667
p.G803V	TCGA-B5-A11E	UCEC	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.3056
p.H795Y	TCGA-BR-8368	STAD	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.2222
p.T807N	TCGA-EO-A3AV	UCEC	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1944
p.P789L	TCGA-FS-A1ZD	SKCM	TCGA	PPDY	ITCH	799:802	Mutation rewiring degron network	0.0556
p.E791Q	DO2401	BRCA	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1111
p.P799S	DO222737	COCA	ICGC	PPDY	ITCH	799:802	Mutation altering degron motif	0.6752
p.P799S	DO25797	LUAD	ICGC	PPDY	ITCH	799:802	Mutation altering degron motif	0.6752
p.L794R	DO234292	ESAD	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1944
p.L794R	DO38360	STAD	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1944
p.D812G	DO223053	ESCA	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.0556
p.L804P	DO44454	HNSC	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.2778
p.Y802N	DO26504	LUSC	ICGC	PPDY	ITCH	799:802	Mutation altering degron motif	0.7059
p.Y802N	DO47569	SKCM	ICGC	PPDY	ITCH	799:802	Mutation altering degron motif	0.7059
p.D812Y	DO26662	LUSC	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.0556
p.D811N	DO219123	LUSC	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.0833
p.R795Q	DO46657	PAAD	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.2222
p.A797V	DO228176	PBCA	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.2778
p.L794H	DO36455	READ	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1944
p.L794H	DO38855	STAD	ICGC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1944
p.P809S	SIDM00780	Colorectal Carcinoma	GDSC	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1389
p.P809S	ACH-000967	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	799:802	Mutation rewiring degron network	0.1389
p.T796I	ACH-000870	Lung Cancer	CCLE	PPDY	ITCH	799:802	Mutation rewiring degron network	0.25
p.N798I	ACH-001520	Leukemia	CCLE	PPDY	ITCH	799:802	Mutation rewiring degron network	0.3056
p.N805K	ACH-002029	Head and Neck Cancer	CCLE	PPDY	ITCH	799:802	Mutation rewiring degron network	0.25

Kaplan plot for NLGN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NLGN1

UniProt ID: Q8N2Q7

Entrez ID: 22871

Protein name: Neuroligin-1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NLGN1 in