DegronMD - Q8N3G9(TMEM130)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R417C	TCGA-DA-A1I7	SKCM	TCGA	PPLY	ITCH	424:427	Mutation rewiring degron network	0.1389
p.E414K	TCGA-EE-A2GO	SKCM	TCGA	PPLY	ITCH	424:427	Mutation rewiring degron network	0.0556
p.S429C	TCGA-G2-AA3D	BLCA	TCGA	PPLY	ITCH	424:427	Mutation rewiring degron network	0.2778
p.R417H	TCGA-J9-A52C	PRAD	TCGA	PPLY	ITCH	424:427	Mutation rewiring degron network	0.1389
p.L423P	TCGA-WS-AB45	COAD	TCGA	PPLY	ITCH	424:427	Mutation rewiring degron network	0.3056
p.E414D	SIDM00534	Colorectal Carcinoma	GDSC	PPLY	ITCH	424:427	Mutation rewiring degron network	0.0556
p.E414D	HT-115	large intestine	COSMIC	PPLY	ITCH	424:427	Mutation rewiring degron network	0.0556
p.L426R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PPLY	ITCH	424:427	Mutation altering degron motif	0.7316
p.V435M	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	424:427	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons