DegronMD - Q8N4B5(PRR18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131T	DO232838	NACA	ICGC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.T114A	DO219881	SKCA	ICGC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1944
p.A112G	DO229208	THCA	ICGC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1389
p.S123L	SIDM00569	Osteosarcoma	GDSC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7667
p.S123L	SIDM01377	Ovarian Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7667
p.S123L	ACH-000351	Gastric Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7667
p.S123L	ACH-000409	Ovarian Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7667
p.S123L	ACH-002178	Bone Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7667
p.A132V	SIDM01242	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0833
p.A132V	ACH-002084	Skin Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0833
p.A132V	ACH-002162	Skin Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.0833
p.T116I	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25
p.T116I	ACH-000865	Esophageal Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons