DegronMD - Q8N543(OGFOD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H238R	TCGA-BR-8591	STAD	TCGA	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.H238R	DO47973	STAD	ICGC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.R255L	TCGA-D3-A2JD	SKCM	TCGA	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.R255L	DO37543	SKCM	ICGC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.R244W	TCGA-EB-A5UN	SKCM	TCGA	PPNY	ITCH	245:248	Mutation rewiring degron network	0.3056
p.R244W	DO47267	SKCM	ICGC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.3056
p.L256I	DO8264	COAD	ICGC	PPNY	ITCH	245:248	Mutation blocking phosphorylation signal	0.5556
p.P246A	DO50930	LICA	ICGC	PPNY	ITCH	245:248	Mutation altering degron motif	0.7503
p.I253M	SIDM00789	Colorectal Carcinoma	GDSC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.I253M	ACH-000997	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.I253M	HCT-15	large intestine	COSMIC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.I253V	SIDM01242	Melanoma	GDSC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.I253V	SIDM01573	Plasma Cell Myeloma	GDSC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.I253V	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.I253V	MMAC-SF	skin	COSMIC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1944
p.P254T	SIDM00520	Mesothelioma	GDSC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.1667
p.E242K	WM35	skin	COSMIC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.25
p.E242G	HT	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.25
p.E243V	TMK-1	stomach	COSMIC	PPNY	ITCH	245:248	Mutation rewiring degron network	0.2778

Kaplan plot for OGFOD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OGFOD1

UniProt ID: Q8N543

Entrez ID: 55239

Protein name: Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog) (uS12 prolyl 3-hydroxylase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OGFOD1 in