DegronMD - Q8N5I2(ARRDC1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y412H	TCGA-EY-A2OQ	UCEC	TCGA	PPEY	ITCH	402:405	Mutation rewiring degron network	0.1389
p.Y412H	TCGA-EY-A2OQ	UCEC	TCGA	PPSY	ITCH	415:418	Mutation rewiring degron network	0.25
p.Y412H	DO41038	UCEC	ICGC	PPEY	ITCH	402:405	Mutation rewiring degron network	0.1389
p.Y412H	DO41038	UCEC	ICGC	PPSY	ITCH	415:418	Mutation rewiring degron network	0.25
p.E413K	DO225158	BRCA	ICGC	PPEY	ITCH	402:405	Mutation rewiring degron network	0.1111
p.E413K	DO225158	BRCA	ICGC	PPSY	ITCH	415:418	Mutation rewiring degron network	0.2778
p.E413K	DO227521	BRCA	ICGC	PPEY	ITCH	402:405	Mutation rewiring degron network	0.1111
p.E413K	DO227521	BRCA	ICGC	PPSY	ITCH	415:418	Mutation rewiring degron network	0.2778
p.P402H	DO230323	COCA	ICGC	PPEY	ITCH	402:405	Mutation altering degron motif	0.7694
p.E404D	DO229031	LICA	ICGC	PPEY	ITCH	402:405	Mutation altering degron motif	0.5647
p.G388V	DO229045	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1944
p.S417F	DO220857	MELA	ICGC	PPSY	ITCH	415:418	Mutation altering degron motif	0.6871
p.Y405H	DO46591	OV	ICGC	PPEY	ITCH	402:405	Mutation altering degron motif	0.834
p.G390R	DO38404	STAD	ICGC	VPTTS	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.25
p.T395A	SIDM00948	Burkitt's Lymphoma	GDSC	VPTTS	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.7139
p.T395A	DG-75	haematopoietic and lymphoid tissue	COSMIC	VPTTS	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.7139
p.P403Q	ACH-000975	Lung Cancer	CCLE	PPEY	ITCH	402:405	Mutation altering degron motif	0.7035

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons