DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
TEX29
UniProt ID:
Q8N6K0
Entrez ID:
121793
Protein name:
Testis-expressed protein 29
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]...
integral component of membrane [GO:0016021]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
TEX29
De
M
E
Y
V
L
E
V
K
N
S
P
R
H
L
L
K
Q
F
T
V
C
D
V
P
L
Y
D
I
C
D
Y
N
V
S
R
D
R
C
Q
E
L
G
C
C
F
Y
E
G
V
C
Y
K
K
A
V
P
I
Y
I
H
V
F
S
A
L
I
V
I
I
A
G
A
F
V
I
T
I
I
Y
R
V
I
Q
E
S
R
K
E
K
A
I
P
V
D
V
A
L
P
Q
K
S
S
E
K
A
E
L
A
S
S
S
S
K
L
G
L
K
P
A
S
P
G
P
P
S
A
G
P
S
M
K
S
D
E
D
K
D
D
V
T
G
T
I
T
E
A
E
E
T
E
D
20
40
60
80
100
120
140
Residue number
0
1
2
3
4
5
6
Number of mutated samples
0
0.5
1
1.5
2
2.5
3
Phosphorylation sites
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CCLE
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Show Degron:
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Degron
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Phosphorylation
Legend: PTM sites
Phosphorylation
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.A108S
DO229041
LICA
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation altering degron motif
0.7588
p.S112N
TCGA-QC-A7B5
SARC
TCGA
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation altering degron motif
0.7069
p.S112N
DO220239
SARC
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation altering degron motif
0.7069
p.K117T
TCGA-VQ-A91S
STAD
TCGA
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation substituting flanking lysine
0.3056
p.K117T
DO222352
STAD
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation substituting flanking lysine
0.3056
p.A105V
DO222813
COCA
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.25
p.G115R
ACH-001569
Skin Cancer
CCLE
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.25
p.L116M
ACH-001853
Bile Duct Cancer
CCLE
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.2222
p.S102R
TCGA-B5-A1MV
UCEC
TCGA
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1667
p.S102R
DO43354
UCEC
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1667
p.S102T
TCGA-B5-A1MV
UCEC
TCGA
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1667
p.S102T
DO43354
UCEC
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1667
p.A119V
SIDM01649
Non-Cancerous
GDSC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1389
p.A119V
SIDM00297
Non-Small Cell Lung Carcinoma
GDSC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1389
p.A119V
SIDM01172
Acute Myeloid Leukemia
GDSC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1389
p.A119V
SIDM00184
Melanoma
GDSC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1389
p.A119V
SIDM01728
Endometrial Carcinoma
GDSC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1389
p.A119V
SIDM01685
B-Lymphoblastic Leukemia
GDSC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.1389
p.P121H
TCGA-AJ-A3EK
UCEC
TCGA
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.0833
p.P121H
DO41584
UCEC
ICGC
ASSSS
DEG_SPOP_SBC_1
108:112
Mutation rewiring degron network
0.0833
Showing 1 to 20 of 21 entries
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Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for TEX29 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc