DegronMD - Q8N6P7(IL22RA1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P361S	TCGA-AD-A5EJ	COAD	TCGA	PPSY	ITCH	361:364	Mutation altering degron motif	0.6752
p.P361S	DO50090	COAD	ICGC	PPSY	ITCH	361:364	Mutation altering degron motif	0.6752
p.A355T	TCGA-IG-A3I8	ESCA	TCGA	PPSY	ITCH	361:364	Mutation rewiring degron network	0.1667
p.Y390C	DO234444	ESAD	ICGC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.0556
p.Q393K	DO233135	GACA	ICGC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.1389
p.T369N	DO229015	LICA	ICGC	PPSY	ITCH	361:364	Mutation rewiring degron network	0.1944
p.M407V	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00087	Plasma Cell Myeloma	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00200	Ewing's Sarcoma	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00917	Acute Myeloid Leukemia	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00203	Ewing's Sarcoma	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM01113	Other Sarcomas	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00032	Bladder Carcinoma	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM01318	Hepatocellular Carcinoma	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.M407V	SIDM00991	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.P396L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.P396L	ACH-002256	Leukemia	CCLE	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.P396L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	400:403	Mutation rewiring degron network	0.2222
p.T369S	SIDM01056	Breast Carcinoma	GDSC	PPSY	ITCH	361:364	Mutation rewiring degron network	0.1944
p.S402F	SIDM00280	Gastric Carcinoma	GDSC	PPSY	ITCH	400:403	Mutation altering degron motif	0.6871
p.S402F	ACH-000560	Gastric Cancer	CCLE	PPSY	ITCH	400:403	Mutation altering degron motif	0.6871
p.S402F	ECC10	stomach	COSMIC	PPSY	ITCH	400:403	Mutation altering degron motif	0.6871

Kaplan plot for IL22RA1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL22RA1

UniProt ID: Q8N6P7

Entrez ID: 58985

Protein name: Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for IL22RA1 in