DegronMD - Q8N806(UBR7)

UBR7

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K274N	TCGA-05-4424	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation blocking ubiquitination signal	0.5278
p.P259Q	TCGA-09-2044	OV	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.2778
p.P259Q	TCGA-ER-A19B	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.2778
p.V272L	TCGA-A5-A0G2	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1389
p.E258K	TCGA-E2-A1IU	BRCA	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.25
p.V251I	TCGA-HD-A6HZ	HNSC	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0556
p.S267C	TCGA-VS-A9V1	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.2778
p.D260Y	DO27421	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D260N	DO232224	PBCA	ICGC	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D260N	DO47769	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.V262I	DO42793	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7076
p.Q273H	DO41361	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc