DegronMD - Q8N9B4(ANKRD42)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E15D	TCGA-06-5416	GBM	TCGA	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2778
p.E15D	DO10880	GBM	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2778
p.R22M	TCGA-2W-A8YY	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.0833
p.R22M	DO223732	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.0833
p.R22M	DO229019	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.0833
p.T16I	TCGA-A3-3365	KIRC	TCGA	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.25
p.T16I	DO19633	KIRC	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.25
p.P9S	TCGA-MP-A4TF	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.6752
p.P9S	DO45316	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.6752
p.A17S	DO228948	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2222
p.G3W	DO229006	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.2778
p.G3R	ACH-000985	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons