FUNCTION: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruitin...
FUNCTION: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625}.
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GO - Biological processes (BP):
cell cycle [GO:0007049]; chromatin organization [GO:0006325]; negative regulation of protein catabolic process [GO:0042177]; protein localization to nucleus [GO:0034504]...
cell cycle [GO:0007049]; chromatin organization [GO:0006325]; negative regulation of protein catabolic process [GO:0042177]; protein localization to nucleus [GO:0034504]
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GO - Molecular function (MF):
DNA binding [GO:0003677]; identical protein binding [GO:0042802]...
DNA binding [GO:0003677]; identical protein binding [GO:0042802]
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GO - Cellular component (CC):
nuclear body [GO:0016604]; nucleoplasm [GO:0005654]...
nuclear body [GO:0016604]; nucleoplasm [GO:0005654]
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