DegronMD - Q8NB59(SYT14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A159S	TCGA-69-7978	LUAD	TCGA	PPPY	ITCH	165:168	Mutation rewiring degron network	0.1667
p.S178L	TCGA-AA-3667	COAD	TCGA	PPPY	ITCH	165:168	Mutation rewiring degron network	0.0556
p.S178L	SIDM01111	Ewing's Sarcoma	GDSC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.0556
p.S178L	SK-ES-1	bone	COSMIC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.0556
p.S161F	TCGA-EE-A2MD	SKCM	TCGA	PPPY	ITCH	165:168	Mutation rewiring degron network	0.2222
p.S159C	DO218351	BTCA	ICGC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.1667
p.E178D	DO9562	COAD	ICGC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.0556
p.G174C	DO233767	GACA	ICGC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.1667
p.G171E	DO52089	HNSC	ICGC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.25
p.H155N	DO20917	KIRP	ICGC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.0556
p.N158Y	DO26210	LUAD	ICGC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.1389
p.Y166N	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	165:168	Mutation altering degron motif	0.7059
p.Y166N	NCI-H2172	lung	COSMIC	PPPY	ITCH	165:168	Mutation altering degron motif	0.7059
p.N158S	U-698-M	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.1389
p.T173I	NCI-H1563	lung	COSMIC	PPPY	ITCH	165:168	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons