DegronMD - Q8NC54(KCT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P90L	TCGA-3N-A9WC	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.6471
p.P90L	DO51234	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.6471
p.K95N	TCGA-AX-A2HD	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778
p.K95N	DO42608	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2778
p.G98V	TCGA-DU-7294	LGG	TCGA	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.G98V	DO22333	LGG	ICGC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.Q83K	TCGA-EE-A3AC	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.Q83K	DO37631	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.T91M	TCGA-QK-A6II	HNSC	TCGA	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.T91M	DO50006	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7423
p.S101F	SIDM01174	Cervical Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.S101F	SIDM00821	Kidney Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.S80Y	ACH-002396	Bone Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons