DegronMD - Q8NCL8(TMEM116)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P235T	TCGA-09-2044	OV	TCGA	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.25
p.P235T	DO28923	OV	ICGC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.25
p.R232P	TCGA-13-1488	OV	TCGA	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.R232P	DO29438	OV	ICGC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.R232C	TCGA-2Y-A9GW	LIHC	TCGA	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.R232C	TCGA-EI-6917	READ	TCGA	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.R232H	TCGA-XK-AAIW	PRAD	TCGA	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.S230L	DO233030	GACA	ICGC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.A239V	DO219774	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.5825
p.R230Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.R230Q	PF-382	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1111
p.A229V	Mewo	skin	COSMIC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.A229G	LoVo	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons