DegronMD - Q8NCP5(ZBTB44)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V346I	TCGA-09-2055	OV	TCGA	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.V346I	TCGA-EC-A24G	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.V346I	DO32676	OV	ICGC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.V346I	DO40996	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.V346I	ACH-002287	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.V346I	NCI-H630	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.S336F	TCGA-61-2111	OV	TCGA	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7982
p.S336F	DO28034	OV	ICGC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7982
p.T384A	TCGA-A5-A0G2	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7139
p.T384A	DO41235	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7139
p.S338Y	TCGA-AG-A002	READ	TCGA	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.712
p.E388D	TCGA-BS-A0UV	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25
p.E388D	DO42793	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25
p.E348D	TCGA-D3-A1Q3	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.E348D	DO47509	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.Q377K	TCGA-DA-A1I7	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.Q377K	DO37951	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.S341L	TCGA-EW-A1IW	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.S341L	DO5500	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25
p.P375S	TCGA-W3-A824	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.P375S	DO51271	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.E388Q	DO224569	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25
p.E388Q	DO1005	BRCA	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25
p.A381S	DO228946	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7588
p.S385R	DO228948	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7427
p.L330I	DO229045	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.P392S	SIDM00528	Breast Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.P392S	ACH-000934	Breast Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.P392S	MDA-MB-361	breast	COSMIC	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.S336C	SIDM01588	Endometrial Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7541
p.S336C	ACH-000993	Endometrial/Uterine Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7541
p.R389L	ACH-001415	Bladder Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB44

UniProt ID: Q8NCP5

Entrez ID: 29068

Protein name: Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB44 in