DegronMD - Q8NCT1(ARRDC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T340A	TCGA-34-5231	LUSC	TCGA	PPNY	ITCH	350:353	Mutation rewiring degron network	0.0556
p.P405A	TCGA-77-8156	LUSC	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.A349T	TCGA-AP-A0LM	UCEC	TCGA	PPNY	ITCH	350:353	Mutation rewiring degron network	0.3056
p.F362L	TCGA-B5-A1MR	UCEC	TCGA	PPNY	ITCH	350:353	Mutation rewiring degron network	0.0833
p.F362L	SIDM00257	Neuroblastoma	GDSC	PPNY	ITCH	350:353	Mutation rewiring degron network	0.0833
p.F362L	ACH-002280	Neuroblastoma	CCLE	PPNY	ITCH	350:353	Mutation rewiring degron network	0.0833
p.F362L	NB13	autonomic ganglia	COSMIC	PPNY	ITCH	350:353	Mutation rewiring degron network	0.0833
p.V401G	TCGA-D3-A2JK	SKCM	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.25
p.D407G	TCGA-DU-6392	LGG	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.0833
p.S363F	TCGA-EE-A2GN	SKCM	TCGA	PPNY	ITCH	350:353	Mutation rewiring degron network	0.0556
p.D407N	TCGA-F1-6874	STAD	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.0833
p.D407N	SIDM01412	Oral Cavity Carcinoma	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.0833
p.D407N	ACH-000762	Head and Neck Cancer	CCLE	PPLY	ITCH	395:398	Mutation rewiring degron network	0.0833
p.R391Q	TCGA-OR-A5LJ	ACC	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.V408I	TCGA-VQ-A91K	STAD	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.0556
p.S399L	TCGA-ZF-AA58	BLCA	TCGA	PPLY	ITCH	395:398	Mutation rewiring degron network	0.3056
p.E389K	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.E389K	ACH-000795	Leukemia	CCLE	PPLY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.E389K	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.V401D	SIDM01242	Melanoma	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.25
p.V401D	MMAC-SF	skin	COSMIC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.25
p.R391W	SIDM00849	Kidney Carcinoma	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.R391W	SIDM00309	Mesothelioma	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.R391W	SIDM00808	Burkitt's Lymphoma	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.R391W	SIDM01254	Burkitt's Lymphoma	GDSC	PPLY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.Y353H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPNY	ITCH	350:353	Mutation altering degron motif	0.7229
p.Y353H	ACH-002222	Leukemia	CCLE	PPNY	ITCH	350:353	Mutation altering degron motif	0.7229
p.Y353H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	350:353	Mutation altering degron motif	0.7229

Kaplan plot for ARRDC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARRDC4

UniProt ID: Q8NCT1

Entrez ID: 91947

Protein name: Arrestin domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARRDC4 in