DegronMD - Q8NDD1(C1orf131)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S24I	TCGA-D1-A17B	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	17:21	Mutation blocking phosphorylation signal	0.6944
p.S24I	DO43017	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation blocking phosphorylation signal	0.6944
p.D8N	TCGA-D8-A27G	BRCA	TCGA	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0833
p.D8N	DO5465	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0833
p.S20F	TCGA-F7-A624	HNSC	TCGA	PGSST	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.9093
p.S20F	DO44440	HNSC	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.9093
p.S24C	DO222857	BTCA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation blocking phosphorylation signal	0.6944
p.L28V	DO229016	COCA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.L28V	DO229505	LAML	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.L28V	DO225404	LAML	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.L28V	DO230527	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.L28V	DO230548	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.L29I	DO233707	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1111
p.S19T	DO233726	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.6005
p.P26Q	DO228976	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.P23S	DO222415	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.T21K	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.8417
p.T21K	ACH-000825	Lung Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.8417
p.S12L	SIDM00837	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.S12L	ACH-000958	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.S25Y	SIDM00118	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.S25Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.T10K	ACH-001278	Ovarian Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	17:21	Mutation blocking phosphorylation signal	0.5833
p.G18A	ACH-001524	Skin Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.6429

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1orf131

UniProt ID: Q8NDD1

Entrez ID: 128061

Protein name: Uncharacterized protein C1orf131

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1orf131 in