DegronMD - Q8NDY8(TMEM52)

GO - Biological processes (BP):

GO - Molecular function (MF):

GO - Cellular component (CC): integral component of membrane [GO:0016021]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PPSY	ITCH	ITCH,NEDD4	Transmembrane protein 52	154:157	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D158N	TCGA-EE-A2MC	SKCM	TCGA	PPSY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.D158N	SIDM00192	Colorectal Carcinoma	GDSC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.K162N	TCGA-EK-A2R8	CESC	TCGA	PPSY	ITCH	154:157	Mutation substituting flanking lysine	0.3056
p.P162A	DO223671	LGG	ICGC	PPSY	ITCH	154:157	Mutation substituting flanking lysine	0.3056
p.P153T	SIDM00834	Colorectal Carcinoma	GDSC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.P153T	ACH-000470	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.P153T	SW1463	large intestine	COSMIC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.L158F	COLO-678	large intestine	COSMIC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.3056
p.E159K	TCGA-DA-A3F8	SKCM	TCGA	PPSY	ITCH	154:157	Mutation rewiring degron network	0.2778
p.R152I	DO230323	COCA	ICGC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.2778
p.P151Q	TCGA-AX-A2HD	UCEC	TCGA	PPSY	ITCH	154:157	Mutation rewiring degron network	0.25
p.P151L	SIDM01526	Mesothelioma	GDSC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.25
p.V161G	TCGA-F5-6814	READ	TCGA	PPSY	ITCH	154:157	Mutation rewiring degron network	0.2222
p.K147N	DO51599	CESC	ICGC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.1389
p.V146G	DO36556	READ	ICGC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.1111
p.A145D	DO228948	LICA	ICGC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.0833
p.A145D	DO229034	LICA	ICGC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.0833
p.E144K	DO37418	SKCM	ICGC	PPSY	ITCH	154:157	Mutation rewiring degron network	0.0556

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Kaplan plot for TMEM52 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM52

UniProt ID: Q8NDY8

Entrez ID: 339456

Protein name: Transmembrane protein 52

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM52 in