DegronMD - Q8NEQ5(C1orf162)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A28V	TCGA-CN-A6V1	HNSC	TCGA	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.A28V	DO52048	HNSC	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.A22S	TCGA-D3-A51T	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.A22S	DO47389	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.S32C	DO874	BOCA	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1667
p.T17S	DO225023	BRCA	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.P29S	DO227999	COCA	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00450	Acute Myeloid Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00544	Neuroblastoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00530	Esophageal Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM01172	Acute Myeloid Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00821	Kidney Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00526	Chronic Myelogenous Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00018	Acute Myeloid Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00655	Other Solid Cancers	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00566	Oral Cavity Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00316	Glioblastoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00554	Ovarian Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00273	Glioblastoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM01582	Gastric Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM00959	Acute Myeloid Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM01753	Gastric Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM01574	Plasma Cell Myeloma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.P29S	SIDM01343	Gastric Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.A28S	DO229041	LICA	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.Q15E	DO229054	LICA	ICGC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.H34Y	SIDM00370	T-Lymphoblastic Leukemia	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.H34Y	SIDM01609	Endometrial Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S26R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7427
p.S26R	ACH-000951	Lung Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1orf162

UniProt ID: Q8NEQ5

Entrez ID: 128346

Protein name: Transmembrane protein C1orf162

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1orf162 in