DegronMD - Q8NFJ8(BHLHE22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R51W	TCGA-34-2600	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.25
p.R51W	DO27081	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.25
p.R51Q	TCGA-CR-7370	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.25
p.R51Q	DO14426	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.25
p.S56F	TCGA-ER-A19F	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.7982
p.S56F	DO37679	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.7982
p.S60L	DO233235	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2778
p.A47V	DO233649	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1389
p.P67T	DO44674	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.0833
p.L62Q	DO35588	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2222
p.R53H	DO38376	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.3056
p.C64F	SIDM00687	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1667
p.C64F	ACH-000793	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1667
p.C64F	KATOIII	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1667
p.S56P	SIDM00537	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.6752
p.S56P	ACH-000982	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.6752
p.S56P	ACH-001345	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.6752
p.S56Y	ACH-000706	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.712
p.L46M	ACH-001061	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1111

Kaplan plot for BHLHE22 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BHLHE22

UniProt ID: Q8NFJ8

Entrez ID: 27319

Protein name: Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5) (Trinucleotide repeat-containing gene 20 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BHLHE22 in